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After the first channel opens, the movement of many types of ions (both inside and outside the cell) alters the distribution of charges near the second channel, causing it to open.

Nội dung chính
    What is the distribution of sodium and potassium ions across a neuron's membrane when it is resting?What is the distribution of ions across neuronal cell membranes?How do sodium ions and potassium ions relate to each other in neurons?What are the relative sodium and potassium levels in relation to the plasma membrane?

***When Na+ ions enter the cell through the first channel, the charge distribution across the membrane changes. Inside the cell, the increase in Na+ ions near the first channel makes that region more positive; as a result, negative ions are attracted to the region, while positive ions are repelled. Conversely, outside of the cell, the loss of Na+ ions makes the region near the first channel more negative; as a result, positive ions are attracted to that region, while negative ions are repelled. Together, all of these ion movements alter the charge (and thus the membrane potential) the neighboring channel, allowing it to reach threshold.

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ability of some chemicals to pass more freely than others through a membrane

That is, some chemicals pass through it more freely than others do. Oxygen, carbon dioxide, urea, and water cross freely through channels that are always open

Several biologically important ions, including sodium, potassium, calcium, and chloride, cross through membrane channels (or gates) that are sometimes open and sometimes closed

When the membrane is rest, the sodium and potassium channels are closed, permitting almost no flow of sodium and only a small flow of potassium. Certain types of stimulation can open these channels, permitting freer flow of either or both ions.

Potassium is subject to competing forces. Potassium is positively charged and the inside of the cell is negatively charged, so the electrical gradient tends to pull potassium in. However, potassium is more concentrated inside the cell than outside, so the concentration gradient tends to drive it out. (For an analogy, imagine a number of women inside a room. Men can enter the room or leave through a narrow door. They are attracted to the women, but when the men get too crowded, some of them leave. The concentration gradient counteracts the attraction.)

If the potassium channels were wide open, potassium would have a small net flow out of the cell. That is, the electrical gradient and concentration gradient for potassium are almost in balance, but not quite. The sodium-potassium pump continues pulling potassium into the cell, counteracting the ions that leak out.

- the principle that once an action potential is triggered in an axon, it is propagated, without decrement, to the end of the fiber

- Action potentials move down the axon towards the axon terminal... ALWAYS

- States that the amplitude and velocity of an action potential are independent of the intensity of the stimulus that initiated it

- In other words, an action potential, once triggered, is transmitted without decreasing in size to the end of the neuron

By analogy, imagine flushing a toilet: You have to make a press of least a certain strength (the threshold), but pressing harder does not make the toilet flush faster or more vigorously. Similarly, when you flick the switch to turn on the lights in your room, flicking the switch harder would not make the lights brighter.

At the resting potential, the sodium channels are fully closed and the potassium channels are almost closed, allowing only a little flow of potassium. As the membrane becomes depolarized, both the sodium and the potassium channels begin to open, allowing freer flow. At first, opening the potassium channels makes little difference, because the concentration gradient and electrical gradient are almost in balance anyway. However, opening the sodium channels makes a big difference, because both the electrical gradient and the concentration gradient tend to drive sodium ions into the neuron. When the depolarization reaches the threshold of the membrane, the sodium channels open wide enough for sodium to flow freely. Driven by both the concentration gradient and the electrical gradient, the sodium ions enter the cell rapidly, until the electrical potential across the membrane passes beyond zero to a reversed polarity, as shown in the following diagram:

What is the distribution of sodium and potassium ions across a neuron's membrane when it is resting?

For a typical neuron rest, sodium, chloride, and calcium are concentrated outside the cell, whereas potassium and other anions are concentrated inside. This ion distribution leads to a negative resting membrane potential.

What is the distribution of ions across neuronal cell membranes?

In neurons, potassium ions are maintained high concentrations within the cell while sodium ions are maintained high concentrations outside of the cell. The cell possesses potassium and sodium leakage channels that allow the two cations to diffuse down their concentration gradient.

How do sodium ions and potassium ions relate to each other in neurons?

The neuronal membrane also contains specialised proteins called channels, which form pores in the membrane that are selectively permeable to particular ions. Thus sodium channels allow sodium ions through the membrane while potassium channels allow potassium ions through.

What are the relative sodium and potassium levels in relation to the plasma membrane?

The membrane is permeable to K+ rest because many channels are open. In a normal cell, Na+ permeability is about 5% of the K+ permeability or even less, whereas the respective equilibrium potentials are +60 mV for sodium (ENa) and −90 mV for potassium (EK). Tải thêm tài liệu liên quan đến nội dung bài viết What is the relative distribution of sodium and potassium ions across a neuronal membrane Quizlet

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